4 edition of Modification of rabbit platelet function in hypercholesterolemia found in the catalog.
Modification of rabbit platelet function in hypercholesterolemia
Peter Lawrence Gross
Thesis (M.Sc.)--University of Toronto, 1991.
|Series||Canadian theses = Thèses canadiennes|
|The Physical Object|
We are committed to sharing findings related to COVID as quickly and safely as possible. Any author submitting a COVID paper should notify us at [email protected] to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID Embelin is a quinone derivative and found in the fruits of Embelia ribes Burm.f. Embelin has been identified as a small molecular inhibitor of X-chromosome-linked inhibitor of apoptosis proteins, and has multiple biological activities, including antioxidation, anti-inflammation, and antitumor effects. However, the effect of embelin in platelets remains : Jiun Yi Li, Jiun Yi Li, Jiun Yi Li, Ray Jade Chen, Li Ting Huang, Tzu Yin Lee, Wan Jung Lu, Kuan Hun.
2 Anatomy and function of vasa vasorum Vasa vasorum branching geometry. The vasa vasorum have been shown to function as end arteries, possibly due to the pressure distribution within the arterial wall which could compress most of the vasa arterial injection of the silicon polymer Microfil® results in high pressure in the arterial lumen and Cited by: Again, according to the cholesterol theory of heart disease, both heredity and diet have a significant influence on a patient’s LDL, HDL and total cholesterol levels. For example, familial hypercholesterolemia is a common inherited disorder whose victims have a diminished number or nonexistent LDL receptors on the surface of liver cells.
A Prospective Study of Application of Platelet Mapping in HBV-related Acute-on-chronic-liver Failure in China. And through the platelet mapping, it can help provide a picture of patients' function of platelet. This study aims to explore the predictive role of platelet mapping in ACLF prognosis, organ failure developments and short term. Platelet counts confirmed that the PRP preparation technique used in this study produced a source of highly concentrated platelets with the collection efficiency  of %(). The average (standard deviation) peripheral blood platelet count and the average PRP platelet count was ()/mm3 and ()/mm3,Cited by: 5.
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Laboratory studies suggest that these differences may be mediated through alterations in platelet fatty acid metabolism in hypercholesterolemia, particularly in thromboxane formation from arachidonate.
In this paper, we shall review our data on platelet function in by: 9. Effect of Factor Xa on Platelet Aggregation and TXA 2 Synthesis in Hypercholesterolemia. To determine whether exposure of platelets to a high cholesterol environment in vivo results in loss of responsiveness to factor Xa similar to that following platelet cholesterol enrichment in vitro, we studied platelets from patients with : Nighat Kahn, Bilal Khan, Asru K.
Sinha. Platelet function and survival in patients wit severe hypercholesterolemia. Corash L, Andersen J, Poindexter BJ, Schaefer EJ.
Platelet aggregation and survival were measured in twelve subjects with severe hypercholesterolemia. There was a small increase in sensitivity to epinephrine and adenosine diphosphate among the most hypercholesterolemic Cited by: Modulation of Rabbit Platelet Aggregation and Calcium Mobilization by Platelet Cholesterol Content Article in Journal of Veterinary Medical Science 72(3).
Platelets derived from patients with homozygous familial hypercholesterolemia (HFH), which demonstrated increased platelet aggregation, failed to cause a similar modification in normal LDL. Similarly, incubation of normal platelets with HFH patient-derived LDL did not cause marked LDL by: This study was designed to elucidate changes in rabbit platelet lipids induced by a cholesterol rich diet and to explore the possible correlation of these lipid changes with platelet abnormalities.
Pronounced biochemical alterations were observed when serum cholesterol levels of – mg% were reached. Hypercholesterolemic (HC) platelets contained 37% more Cited by: In labelling of platelets.
Full details of the protocol for the isolation and radiolabelling of rabbit platelets have been described elsewhere (May et al., ).Briefly, 9 ml blood was collected from the right ear artery into 1 ml % (w v −1) trisodium citrate and centrifuged (×g for 15 min) to obtain platelet-rich plasma (PRP).
PRP was buffered in Ca 2+-free Tyrode solution Cited by: Discussion Thrombosis is seen only very rarely, if ever at all, in rabbits fed cholesterol alone or along with other fats or fatty acids even if severe atherosclerosis is present and even if a hypercoagulable state exists as determined by various in vitro tests of blood coagulation, platelet aggregation and platelet function (6).Author: B.I.
Weigensberg, B. Mullen, A. Sumiyoshi, V. Senicas, T. Creatchman, A. Mok, S. Davis, S. Friedland. Enzymatic modification of plasma low density lipoproteins in rabbits: A potential treatment for hypercholesterolemia.
and platelet counts showed no net. On the other hand, cholesterol enrichment in platelets augmented thrombin-induced aggregation and Ca 2+ mobilization.
These findings suggest that cholesterol plays a critical role in regulating rabbit platelet activation, and provides fundamental information regarding hypercholesterolemia-mediated effects on cells in the rabbit by: 4. Familial hypercholesterolemia (FH) is a genetic disorder characterized by high cholesterol levels, specifically very high levels of low-density lipoprotein (LDL, "bad cholesterol"), in the blood and early cardiovascular the underlying body biochemistry is slightly different in individuals with FH, their high cholesterol levels are less responsive to the kinds of cholesterol Specialty: Endocrinology.
Plasma exchange in patients with hypercholesterolemia was described to have a beneficial effect on platelet function in vitro; 3 however, in that study, the plasma exchange technique used was probably not selective for apo B-containing particles.
3 In contrast to these positive data, it has been shown that the enhanced in vitro sensitivity of. The hypothesis of oxidative modification in atherosclerosis, reviewed by Steinberg and others in several opportunities argues that the oxidation of low-density lipoprotein (LDL) is an early stage of the disease and that oxidized LDL (OxLDL) would contribute to atherogenesis .Cited by: 5.
Familial hypercholesterolemia (FH) is an autosomal codominant genetic disorder of lipoprotein metabolism, usually caused by mutations in the low‐density lipoprotein (LDL) receptor (LDLR) gene or other genes that affect LDLR ts can be heterozygous (HeFH) with one mutated allele, homozygous (HoFH) with two identical mutations, or compound heterozygous Author: Min‐Ji Charng.
Platelet Function in Patients With Hemophilia A The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
Listing a study does not mean it has been evaluated by the U.S. Federal Government. Hospital rabbit (VLDL, IDL, and LDL elevated) serve as models for familial hypercholesterolemia and familial combined hyperlipidemia, respectively. Homozygous WHHL rabbits and St. Thomas’ Hospital rabbits predictably develop atherosclerotic lesions on normal diets.
Finally, there are at least 19 transgenic rabbit. In conclusion, hyperlipoproteinemia is associated with certain aspects of platelet activation,and particularly so in patients with combined hyperlipidemia. Reduction of plasma lipoproteinlevels does not improve platelet function in vivo.
On the contrary, some lipid-lowering agentsmay even have platelet activating effects. The interaction of platelets with subendothelial components was explored in a perfusion system in which blood was exposed (shear rate, /s; 10 minutes) to denuded segments of rabbit aorta.
Platelet interactions in these perfusions were analyzed by: INTRODUCTION. The megakaryocyte is the hematopoietic cell that produces platelets.
Evidence for this relationship was first provided in by James Homer Wright, who demonstrated that circulating platelets and a giant bone marrow cell now known to be the megakaryocyte shared common tinctorial properties when subjected to a modified Romanowsky stain .
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Special Precautions & Warnings. Platelet aggregation was measured by slight modification of previously described method [29,30,31]. Plasma obtained from a species was mixed with 10 units/mL of heparin and centrifuged at g for 15 min. The platelet rich plasma (PRP) thus obtained was centrifuged at g for 15 min and the resulting platelet pellet was washed with by: 1.Familial hypercholesterolemia (FH) is a cholesterol problem found in families.
Many people have high cholesterol but people with FH have very high cholesterol, starting in childhood or even at birth. People with FH also often have a pattern in their family history of early heart disease.
Cholesterol levels can vary, but FH isFile Size: KB.ISBN: OCLC Number: Notes: "Proceedings of the Sixth International Symposium on Atherosclerosis Held in Berlin, June th,In cooperation with the International Society and Federation of Cardiology."- .